Epigenetic regulation of glioma stem-like cell differentiation
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چکیده
CAPSULE Background: Molecular mechanisms underlying heterogeneity of glioblastoma are poorly understood. Result: Newly identified microRNA-1275, which is controlled by a polycomb-mediated silencing mechanism, regulates expression of oligodendroglial lineage gene, CLDN11, in glioma stem-like cells. Conclusion: MicroRNA-1275 may contribute to the establishment of tissue heterogeneity via epigenetic mechanisms. Significance: We identified a microRNA that is associated with tumor cell differentiation in the oligodendroglial lineage. SUMMARY
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تاریخ انتشار 2012